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Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory activity. The review contains also the information about structure–¶activity relationships with respect to natural or semisynthetic origin of compounds and synergy effects between natural dual inhibitors and commercially available antibiotics. Data published from 2000 to 2018 were obtained using databases Google Scholar, Science Direct and Web of Science, and searching keywords such as alkaloids , anti - inflammatory activity , antimicrobial activity , chalcones , coumarins , flavonoids , IC 50 , lignans , MIC , natural compounds , synergistic effect and terpenoids , alone or in a combination cannabis seeds.
   
    
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